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. 2017 Aug 17;12(8):e0183124. doi: 10.1371/journal.pone.0183124

Fig 5. Concentration-response curves to acetylcholine (ACh) before/after incubation with charybdotoxin (Cha, 1 μmol/l) and apamin (1 μmol/l) in phenylephrine (PE)-preconstricted renal arcuate arteries (n = 5).

Fig 5

The incubation with Cha and apamin decreased vasodilation in lean control rats (A), but no alternation was seen in obese Zucker (OZ) rats (B). Incubation with L-NNA, indomethacin (Indo), Cha, and apamin almost abolished vasodilation induced by ACh in both lean and OZ rats (A and B). NS 1619 elicited a concentration-dependent vasodilation in PE-preconstricted renal arcuate arteries (C). However, the vasodilation induced by 1, 10 and 50 μmol/l was decreased in OZ rats (C). ** P<0.001, *P<0.05.