Table 1. Comparison of clinicopathological variables according to MHC-II expression in tumor cells.
MHC-II expression | ||||
---|---|---|---|---|
No (n = 479) | Low* (n = 86) | High* (n = 116) | p value | |
Histological grade | 0.041 | |||
1 | 0 | 0 | 0 (0.0%) | |
2 | 21 (18.1%) | 14 (16.3%) | 126 (26.3%) | |
3 | 95 (81.9%) | 72 (83.7%) | 353 (73.7%) | |
Pathologic T stage | 0.074 | |||
1 | 213 (44.5%) | 45 (52.3%) | 41 (35.3%) | |
2 | 243 (50.7%) | 40 (46.5%) | 73 (62.9%) | |
3 | 22 (4.6%) | 1 (1.2%) | 2 (1.7%) | |
4 | 1 (0.2%) | 0 | 0 | |
Lymph node metastasis | 0.726 | |||
Negative | 332 (69.3%) | 57 (66.3%) | 83 (71.6%) | |
Positive | 147 (30.7%) | 29 (33.7%) | 33 (28.4%) | |
Lymphovascular invasion | 0.042 | |||
Negative | 355 (74.1%) | 69 (80.2%) | 98 (84.5%) | |
Positive | 124 (25.9%) | 17 (19.8%) | 18 (15.5%) | |
TILs (%) | <0.001 | |||
≤ 10 | 144 (30.1%) | 13 (15.1%) | 8 (6.9%) | |
20–30 | 118 (24.6%) | 16 (18.6%) | 20 (17.2%) | |
40–60 | 95 (19.8%) | 19 (22.1%) | 34 (29.3%) | |
>60 | 122 (25.5%) | 38 (44.2%) | 54 (46.6%) | |
Peritumoral lymphocytes (Klintrup criteria) | <0.001 | |||
0 | 40 (8.4%) | 2 (2.3%) | 0 (0.0%) | |
1 | 194 (40.5%) | 21 (24.4%) | 21 (18.1%) | |
2 | 184 (38.4%) | 45 (52.3%) | 57 (49.1%) | |
3 | 61 (12.7%) | 18 (20.9%) | 38 (32.8%) | |
TLS adjacent to the invasive area | <0.001 | |||
No | 50 (10.4%) | 4 (4.7%) | 1 (0.9%) | |
Mild | 85 (17.7%) | 12 (14.1%) | 12 (10.3%) | |
Moderate | 173 (36.1%) | 36 (41.9%) | 42 (36.2%) | |
Severe | 171 (35.7%) | 34 (39.5%) | 61 (52.6%) | |
MHC class I expression | <0.001 | |||
Low | 271 (58.0%) | 33 (38.4%) | 11 (9.5%) | |
High | 196 (42.0%) | 53 (61.6%) | 105 (90.5%) | |
PD-L1 expression | <0.001 | |||
Negative | 440 (96.7%) | 74 (87.1%) | 83 (71.6%) | |
Positive (any) | 15 (3.3%) | 11 (12.9%) | 33 (28.4%) | |
MxA expression | <0.001 | |||
Low | 321 (67.9%) | 48 (55.8%) | 50 (43.1%) | |
High | 152 (32.1%) | 38 (44.2%) | 66 (56.9%) | |
PKR expression | 0.008 | |||
Low | 256 (54.6%) | 37 (43.0%) | 47 (40.5%) | |
High | 213 (45.4%) | 49 (57.0%) | 69 (59.5%) |
*The expression of MHC-II molecules was dichotomized into low and high groups using the mean of the immunoreactive score, 27.2; MxA, myxovirus resistance A; PKR, double-stranded RNA-activated protein kinase; TILs, tumor infiltrating lymphocytes; TLS, tertiary lymphoid structure.