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. 2017 Aug 17;12(8):e0183049. doi: 10.1371/journal.pone.0183049

Fig 4. Comparison of galactosyl transferases from C. elegans, D. melanogaster (fly), and humans.

Fig 4

Alignments were made of the most closely-related C. elegans (wormbase), fly (FBgn0027538, FBgn0031495) and human (Q8NCL4, Q10472) galactosyltransferases using CLUSTAL [47]. The ngat-1(ev821) nonsense mutation is indicated by blue triangles and the position of the Leu (or in this case Ile) residue, which specifies N-acetylgalactosamine transfer (vs Tyr or Phe, which do not) [48] is indicated by red triangles. Metal ion (red underline), acceptor (blue underline), and donor (green underline) binding sites as predicted from human galactosyl transferases [45]. Identical residues are shaded black and similar residues are shaded grey.