Table 4. Trace element concentrations reported in mature human milk.
Trace Element | Country | Analysis Methoda | n | Median | M b | SD | Unit | Reference |
---|---|---|---|---|---|---|---|---|
Calcium | ||||||||
Brazil | ICP-AES | 31 | 250 | 31 | mg/L | [35] | ||
Gambia | Methyl thymol blue | 120 | 208.93c | 24 | mg/L | [29] | ||
Japan | ICP-AES | 1170 | 250 | 71 | mg/L | [36] | ||
Nigeria | Thermo Labsystems Arsenazo III Kit | 105 | 186 | 41 | mg/L | [37] | ||
Sweden | ICP-MS | 60 | 305 | 45 | mg/L | [12] | ||
US | AAS | 20 | 279.2 | 127.90 | mg/L | [38] | ||
Copper | ||||||||
Brazil | AAS | 116 | 0.3 | 0.1 | mg/L | [39] | ||
Honduras | AAS | 105 | 0.16 | 0.21 | mg/L | [40] | ||
Japan | ICP-AES | 1169 | 0.35 | 0.21 | mg/L | [36] | ||
Kuwait | AAS | 17 | 0.608c | 0.027 | mg/L | [41] | ||
Poland | GF AAS | 320 | 0.137 | 0.092 | mg/L | [42] | ||
Sweden | AAS | 86 | 0.12 | 0.22 | mg/L | [40] | ||
Sweden | ICP-MS | 60 | 0.471 | 0.075 | mg/L | [12] | ||
Turkey | ICP-OES | 75 | 0.446c | 0.197 | mg/L | [13] | ||
US | AAS | 30 | 0.27 | 0.11 | mg/L | [38] | ||
Vietnam | ICP-AES | 59 | 0.19 | 0.05 | mg/L | [43] | ||
Iron | ||||||||
India | AAS | 16 | 0.168c | 0.406 | mg/L | [44] | ||
Brazil | ICP-AES | 31 | 0.9 | 0.5 | mg/L | [35] | ||
Brazil | AAS | 116 | 0.3 | 0.2 | mg/L | [39] | ||
Honduras | AAS | 105 | 0.21 | 0.25 | mg/L | [40] | ||
Japan | ICP-AES | 1155 | 1.19 | 2.51 | mg/L | [36] | ||
Japan | AAS | 24 | 0.32 | 0.16 | mg/L | [45] | ||
Kuwait | AAS | 17 | 0.4c | 0.040 | mg/L | [41] | ||
Sweden | AAS | 86 | 0.29 | 0.21 | mg/L | [40] | ||
Sweden | ICP-MS | 60 | 0.339 | 0.134 | mg/L | [12] | ||
Turkey | ICP-OES | 75 | 1.072c | 0.841 | mg/L | [13] | ||
US | AAS | 41 | 0.36 | 0.19 | mg/L | [38] | ||
Vietnam | ICP-AES | 59 | 0.43 | 0.15 | mg/L | [43] | ||
Manganese | ||||||||
Brazil | ICP-MS | 58 | 0.33 | ug/L | [46] | |||
Japan | ICP-AES | 1167 | 11 | 23 | ug/L | [36] | ||
Japan | AAS | 24 | 9.5 | 6.3 | ug/L | [45] | ||
Kuwait | AAS | 17 | 4.71c | 0.16 | ug/L | [41] | ||
Sweden | ICP-MS | 60 | 3 | 11.4 | ug/L | [12] | ||
Turkey | ICP-OES | 74 | 124c | 156 | ug/L | [13] | ||
US | AAS | 116 | 4.9 | 3.9 | ug/L | [33] | ||
Zinc | ||||||||
Brazil | ICP-AES | 31 | 1.5 | 0.6 | mg/L | [35] | ||
Brazil | AAS | 116 | 2.7 | 1.3 | mg/L | [39] | ||
Brazil | ICP-MS | 58 | 0.0462 | mg/L | [46] | |||
Honduras | AAS | 105 | 0.7 | 0.18 | mg/L | [40] | ||
India | AAS | 50 | 2.5 | mg/L | [47] | |||
India | AAS | 47 | 1.37 | mg/L | [47] | |||
India | AAS | 50 | 1.17 | mg/L | [47] | |||
Japan | ICP-AES | 1165 | 1.45 | 1.35 | mg/L | [36] | ||
Kuwait | AAS | 17 | 2.56c | 0.136 | mg/L | [41] | ||
Poland | GF AAS | 320 | 1.62 | 1.76 | mg/L | [42] | ||
Sweden | AAS | 86 | 0.46 | 0.26 | mg/L | [40] | ||
Sweden | ICP-MS | 60 | 3.471 | 0.979 | mg/L | [12] | ||
Turkey | ICP-OES | 75 | 3.454 | 1.970 | mg/L | [13] | ||
US | AAS | 30 | 1.45 | 1.37 | mg/L | [38] | ||
Vietnam | ICP-AES | 59 | 0.56 | mg/L | [43] | |||
Arsenic | ||||||||
Croatia | ICP-MS | 123 | 0.2 | ug/L | [48] | |||
Greece | ICP-MS | 39 | 0.8 | ug/L | [48] | |||
Italy | ICP-MS | 602 | 0.3 | ug/L | [48] | |||
Japan | ICP-MS | 9 | 1.4 | ug/L | [49] | |||
Slovenia | ICP-MS | 287 | 0.4 | ug/L | [48] | |||
Sweden | ICP-MS | 60 | 0.33 | 0.041 | ug/L | [12] | ||
Taiwan | AAS | 90 | 0.215c | 0.81 | ug/L | [50] | ||
Lead | ||||||||
Brazil | ICP-MS | 58 | 0.26 | ug/L | [45] | |||
Iran | AAS | 37 | 7.11 | 3.96 | ug/L | [51] | ||
Iraq | AAS | 32 | 31.65 | 22.19 | ug/L | [14] | ||
Iraq | AAS | 36 | 19.59 | 13.66 | ug/L | [14] | ||
Japan | ICP-MS | 9 | 0.29 | ug/L | [49] | |||
Palestine | GF AAS | 89 | 4 | ug/L | [11] | |||
Poland | GF AAS | 320 | 6.33 | 4.61 | ug/L | [42] | ||
Sweden | ICP-MS | 60 | 1.5 | 0.9 | ug/L | [12] | ||
Taiwan | AAS | 90 | 17.17c | 2.18 | ug/L | [50] | ||
Turkey | ICP-OES | 56 | 261c | 171 | ug/L | [13] |
a Abbreviations: AAS = Atomic Absorption Spectroscopy, GF AAS = Graphite Furnace Atomic Absorption Spectroscopy, ICP-AES = Inductively Coupled Plasma Atomic Emission Spectroscopy, ICP-MS = Inductively Coupled Plasma Mass Spectrometry, ICP-OES = Inductively Coupled Plasma Optical Emission Spectrometry
b Means have been standardized to a common unit for each element.
c Weighted population mean calculated with data reported for sub-groups.