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. 2017 Aug 17;12(8):e0183572. doi: 10.1371/journal.pone.0183572

Table 4. List and subgrouping of the top hits of highly differentially expressed genes (fold change ≥ 50 or ≤ -50) in canine M2- vs. M0-macrophages.

Gene name Gene symbol Fold change
Up-regulated genes
Cell surface markers
Lymphatic vessel endothelial hyaluronan receptor 1 LYVE1 322.32
Succinate receptor 1 SUCNR1 151.91
CD1e molecule CD1E 147.40
Mannose receptor, C type 1 MRC1 104.41
Tetraspanin 7 TSPAN7 83.25
Junctional adhesion molecule 3 JAM3 78.46
Anthrax toxin receptor 1 ANTXR1 72.95
Membrane-spanning 4-domains, subfamily A, member 2 MS4A2 54.98
C-type lectin domain family 4, member G CLEC4G 54.14
Enzymes
ADP-ribosylhydrolase like 2 ADPRHL2 614.52
Guanine deaminase GDA 174.44
Ubiquitin-conjugating enzyme E2 C-like LOC481325 151.23
Ribonucleotide reductase M2 RRM2 131.03
Fructose-1,6-bisphosphatase 1 FBP1 57.95
Matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) MMP9 56.03
Lipoprotein lipase LPL 52.03
Trimethyllysine hydroxylase, epsilon TMLHE 51.05
3-hydroxybutyrate dehydrogenase, type 2 BDH2 50.68
Cytokines, chemokines, and their receptors
Chemokine (C-C motif) ligand 24 CCL24 1060.82
Chemokine (C-X-C motif) receptor 7 ACKR3 390.67
Chemokine (C-C motif) ligand 17 CCL17 209.36
Chemokine (C-C motif) ligand 13 CCL13 172.58
Interleukin 13 receptor, alpha 2 IL13RA2 170.59
Transforming growth factor, beta 2 TGFB2 61.84
Soluble factors
Nephronectin NPNT 444.07
Norrie disease (pseudoglioma) NDP 213.72
Endothelin 1 EDN1 115.81
Cystatin 9 (testatin) CST9 58.21
Miscellaneous
Sodium channel, voltage-gated, type II, beta subunit SCN2B 1061.28
Caldesmon 1 CALD1 224.66
CXADR-like membrane protein CLMP 169.27
SHC SH2-domain binding protein 1 SHCBP1 117.77
Dynamin 1 DNM1 112.78
NACC family member 2, BEN and BTB (POZ) domain containing NACC2 110.49
Retinoic acid induced 14 RAI14 84.35
Scinderin SCIN 71.66
Kinesin family member 23 KIF23 66.78
Kinesin family member 11 KIF11 64.20
Cfa-mir-125b-2 cfa-mir-125b-2 58.78
AHNAK nucleoprotein AHNAK 57.19
NUF2, NDC80 kinetochore complex component NUF2 54.62
Down-regulated genes
Cell surface markers
Integrin, beta 8 ITGB8 -199.37
Lymphocyte antigen 6 complex, locus E LY6E -116.70
T cell receptor delta constant TRDC -112.73
Natural cytotoxicity triggering receptor 3 NCR3 -105.99
Selectin L SELL -95.45
Sialic acid binding Ig-like lectin 1, sialoadhesin SIGLEC1 -91.39
Killer cell lectin-like receptor subfamily D, member 1 KLRD1 -87.12
Killer cell lectin-like receptor subfamily B, member 1 KLRB1 -74.56
Membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) MPP6 -72.60
Purinergic receptor P2Y, G-protein coupled, 14 P2RY14 -71.69
T cell receptor beta constant 2 TRBC2 -64.26
TCR gamma alternate reading frame protein TARP -62.39
Fc receptor-like A FCRLA -60.06
Potassium channel, subfamily K, member 5 KCNK5 -58.16
Purinergic receptor P2X, ligand-gated ion channel, 5 P2RX5 -58.16
Natural killer cell group 7 sequence NKG7 -57.26
CD69 molecule CD69 -54.53
CD7 molecule CD7 -52.57
Enzymes
Interferon stimulated exonuclease gene 20kDa ISG20 -514.04
Prostaglandin E synthase PTGES -382.20
Cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial CMPK2 -266.50
Granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) GZMA -131.27
Granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) GZMB -130.63
Hexokinase 3 (white cell) HK3 -127.10
Ubiquitin specific peptidase 18 USP18 -81.72
Phospholipase A1 member A PLA1A -72.65
Cathepsin E CTSE -72.13
GTP cyclohydrolase 1 GCH1 -66.29
Chymase 1, mast cell CMA1 -61.45
Phospholipid scramblase 1-like LOC611500 -61.09
Cytokines, chemokines, and their receptors
Chemokine (C-X-C motif) ligand 12 CXCL12 -417.05
Interleukin 2 IL2 -195.40
Interleukin 7 receptor IL7R -66.71
Transforming growth factor, beta receptor III TGFBR3 -50.94
Soluble factors
Lipocalin 2 LCN2 -217.74
Adrenomedullin ADM -100.37
Miscellaneous
Radical S-adenosyl methionine domain containing 2 RSAD2 -559.34
Interferon-induced transmembrane protein 3-like LOC606890 -435.57
ISG15 ubiquitin-like modifier ISG15 -254.32
Apolipoprotein L, 5 APOL5 -200.23
Fatty acid binding protein 4, adipocyte FABP4 -182.17
Interferon-induced protein with tetratricopeptide repeats 1 IFIT1 -142.72
Interferon regulatory factor 4-like LOC609817 -118.68
Carcinoembryonic antigen-related cell adhesion molecule 25 CAECAM1 -113.27
Interferon regulatory factor 7 IRF7 -102.93
OCIA domain containing 2 OCIAD2 -100.84
Piwi-like RNA-mediated gene silencing 4 PIWIL4 -97.75
Synaptotagmin-like 3 SYTL3 -94.94
Testis expressed 14 TEX14 -92.58
Myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) MX1 -91.32
Structural maintenance of chromosomes flexible hinge domain containing 1 SMCHD1 -84.97
Interferon-induced transmembrane protein 1-like LOC475935 -83.91
eukaryotic peptide chain release factor GTP-binding subunit ERF3B-like LOC480921 -74.06
Lactotransferrin LTF -72.08
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 DDX58 -69.54
TNFAIP3 interacting protein 3 TNIP3 -58.03
Syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) SNTB1 -55.46
Src kinase associated phosphoprotein 1 SKAP1 -50.58