Table 2. Clinical, virologic and neurological outcome in macaques inoculated with CL757.
| Animal ID* | Survival (weeks) | Plasma viral load (copies/ml) |
CSF viral load (copies/ml) | Clinical symptoms of neurological disease | Inoculum | TRIM5 genotype |
|---|---|---|---|---|---|---|
| H880 | 58 | 1.3 x 106 | 1.4 x 107 | Slow/staggered gait Arm tremors Hiding–hunched in back of cage |
CL757 | TFP/Q |
| H881 | 49 | 1.0 x 106 | 1.2 x 104 | None | CL757 | TFP/Q |
| H882 | 70 | 3.8 x 105 | 1.0 x 107 | None | CL757 | Q/Cyp |
| H883 | 98 | 3.0 x 105 | 7.6 x 103 | None | CL757 | Q/Cyp |
| H884 | 105 | 1.6 x 106 | 4.6 x 104 | None | CL757 | Q/Cyp |
| H885 | 53 | 3.2 x 106 | 4.8 x 103 | None | CL757 | Q/Q |
| H886 | 54 | 3.2 x 106 | 4.6 x 106 | Anisocoria Nystagmus Ataxia Head pressing/holding |
CL757 | Q/Q |
| H887 | 54 | 2.4 x 106 | 1.6 x 108 | Anisocoria Nystagmus Ataxia Head pressing/holding Partial hind limb paralysis |
CL757 | Q/Q |
| H842 | 90 | 5.2 x 106 | 2.0 x 108 | None | CL757 and E543-3 | TFP/Q |
| H843 | 95 | 2.1 x 105 | 1.4 x 107 | None | CL757 and E543-3 | TFP/Q |