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. Author manuscript; available in PMC: 2018 Aug 8.
Published in final edited form as: Lab Chip. 2017 Aug 8;17(16):2805–2813. doi: 10.1039/c7lc00668c

Fig. 2. Integrated SMR with feedback pressure control for LPNP synthesis.

Fig. 2

(a) Decomposition of the SMR into equivalent fluidic circuit analog for mesh current analysis modelling of the dual pressure control integrated with SMR. Where P represents the inlet pressure of the SMR set by the pressure control system, i_1 and i_2 represent the fluid flow through the system defined by the mesh current analysis method, and R represent the defined resistances of the SMR. (b) Relationship of Reynolds number to the pressure from the mesh current analysis. (c) Control system performance with Reynolds number within the synthesis range. (d, e) Performance of our custom feedback pressure control system (PC) to syringe pump (SP) for (d) transient and (e) steady-state responses. The size distributions and polydispersity index (PDI) of LPNPs produced for (f, g) the steady-state period of the following 2.5 minutes (n=4; *p=0.0221) and (h, i) the transient period of the beginning 5 seconds (n=3; **p=0.0178). PC is our pressure control system and SP is a commercial syringe pump. Significance was determined by a two-tailed unpaired t-test.