. 2017 May 26;206(4):1969–1984. doi: 10.1534/genetics.117.200642

Table 3. Overview of selected candidate genes for aggressive behavior of flies reared in a socialized or socially isolated environment, and GSEI; identified with single marker regression or with genomic prediction following genetic decomposition to genes $>$ 10% of the genetic variance.

Drosophila Gene Symbol	Drosophila Gene Name	SMR	GFBLUP	Prior Associations with Drosophila Aggression	Human Ortholog	Selected Human Associations (Reference)
abd-A	abdominal A		S	5	HOXA6
Ady43A	Ady43A		S, I		ADK
AP-2σ	Adaptor Protein complex 2, σ subunit		S^a		AP2S1
Cad87A	Cadherin 87A	G		2, 3, 5	CDH23	Bipolar disorder (Winham et al. 2013)
CASK	CASK		S, G		CASK
CG11486	CG11486	S		3	PAN3
CG13868	CG13868	I		4
CG17821	CG17821		S^a		ELOVL5
CG2794	CG2794		S, I
CG31141	CG31141		S^a		ELOVL1
CG42458	CG42458	G		3	HNRNPC	Bipolar disorder (Smith et al. 2011)
chb	chromosome bows		I^a		CLASP1
CtBP	C-terminal Binding Protein		S	2	CTBP1, CTBP2
cv-c	crossveinless c		I, G^a	2, 3, 4	DLC1
dally	division abnormally delayed	S		3	GPC5
DNaseII	Deoxyribonuclease II	G		5	DNASE2, DNASE2B
Dys	Dystrophin		S, G^a	2, 5	DMD	Anxiety in depression (Schosser et al. 2013), response to antidepressant treatment in depression (Clark et al. 2012), and bipolar disorder and schizophrenia (Wang et al. 2010b)
eca	eclair		S	6	TMED4
EcR	Ecdysone receptor		S	3	NR1H3
egl	egalitarian		S	5	EXD1
Egfr	Epidermal growth factor receptor		S^a, I		ERBB4/EGFR
Eip75B	Ecdysone-induced protein 75B		S	2	NR1D2
Elo68β	Elongase 68β		S^a		ELOVL4
Fas3	Fasciclin 3		G		CADM1, CADM4, NECTIN3
Frq2	Frequenin 2		S^a, G		NCS1	Alzheimer’s disease (Sherva et al. 2014)
ftz-f1	ftz transcription factor 1		S	2	NR5A1, NR5A2
Gug	Grunge		S	3, 5	RERE	Schizophrenia (Sherva et al. 2014)
kirre	kin of irre	S		3	KIRREL, KIRREL3
lbl	ladybird late		S	2	LBX1
Myo61F	Myosin 61F		I	5	MYO1C
nwk	nervous wreck	I		1	FCHSD2
osa	osa	G			ARID1A, ARID1B
pnt	pointed		S^a		ETS1	Depression and manic episodes in bipolar disorder (Fabbri and Serretti 2016)
Ptp99A	Protein tyrosine phosphatase 99A	S		2, 5	PTPRG	Alzheimer’s disease (Herold et al. 2016)
pyd	polychaetoid		S	2	TJP1, TJP2	Response to antipsychotic treatment (Clark et al. 2012)
rb	ruby		S	5	AP3B1
Rbfox1	RNA-binding Fox protein 1	I		2, 3, 4	RBFOX1, RBFOX2, RBFOX3	Alzheimer’s disease (Herold et al. 2016) and schizophrenia (Goes et al. 2015)
RecQ4	RecQ4 helicase	G	G		RECQL4
rhea	rhea		S, I		TLN2	Sleep (Byrne et al. 2013) and brain structure (Stein et al. 2010)
salm	spalt major		S	5	SALL1
sgl	sugarless		S^a	5, 6	UGDH
shg	shotgun		S	3	CDH20
sina	seven in absentia		S	3	SIAH1
slou	slouch		S	2	NKX1-1
spg	sponge	S			DOCK3
Syn	Synapsin	G			SYN3
Ten-a	Tenascin accessory	G		3, 5	TENM3	Schizophrenia (Goes et al. 2015)
Timp	Tissue inhibitor of metalloproteases	G		2	TIMP1, TIMP2, TIMP3
Tl	Toll		G	5	TLR3, TLR9	Bipolar disorder (Psychiatric GWAS Consortium Bipolar Disorder Working Group 2011) and schizophrenia (Ripke et al. (2013)
tow	target of wingless	G			C1orf21
trv	trivet	G		3	TIA1
wg	wingless		S^a		WNT1
zormin	zormin	I		5	PALLD, MYPN

Genes previously associated with Drosophila aggressive behavior are indicated by the numbers 1–6: 1, GWAS on the DGRP (Shorter et al. 2015); 2, GWAS on advanced intercross population created from the DGRP (Shorter et al. 2015); 3, epistatic interaction network derived from the DGRP (Shorter et al. 2015); 4, functional validation of candidate genes identified by Shorter et al. (2015); 5, differentially expressed genes between Drosophila lines selected for high and low aggressive behavior (Edwards et al. 2006); 6, mutational screen using P-elements (Edwards et al. 2009). Human orthologs and their selected associations with human quantitative traits and psychiatric disorders are listed. SMR, single marker regression; GFBLUP, genomic feature best linear unbiased prediction; S, socialized; I, socially isolated; GSEI, genotype-by-social environmental interaction; GO, gene ontology; DGRP, Drosophila Genetic Reference Panel; GWAS, genome-wide association study.

Indicates a gene (capturing $>$ 10% of genetic variance within the predictive GO term) that was identified in multiple GO terms.

Table 3. Overview of selected candidate genes for aggressive behavior of flies reared in a socialized or socially isolated environment, and GSEI; identified with single marker regression or with genomic prediction following genetic decomposition to genes >10% of the genetic variance.

Table 3. Overview of selected candidate genes for aggressive behavior of flies reared in a socialized or socially isolated environment, and GSEI; identified with single marker regression or with genomic prediction following genetic decomposition to genes $>$ 10% of the genetic variance.