(
A–D) Modularity and community size of the functional sub-networks based on domains related to signaling (
Richter and King, 2013), ubiquitination (
Grau-Bové et al., 2015), ECM (
Richter and King, 2013;
Sebé-Pedrós et al., 2010;
Hynes, 2012) and protein binding (
Mitchell et al., 2015) functions. Blue dots indicate real genomes, and the purple density plot indicates the values of the simulated rewired networks. Monotonic dependence between modularity and domains/community was tested for each set of data using Spearman's rank correlation coefficient (
ρs); linear regression fits are included for clarity. All sub-networks (
A–D) have the same decreasing trend as the global sub-network of
Figure 8A–B, and contrast with the results for TFs. (
E–H) Modularity of the functional sub-network based on domains related to signaling, ubiquitination, ECM and protein binding functions (same domains as in A-D), per species or ancestral node (colored dots). Purple box plots represent the distribution of simulated modularities from 100 rewirings of the original organism-specific networks, while keeping a constant vertex degree distribution. Note the decreased modularities shown by metazoans (red and pink) in all sub-networks.