Table 1.

Microarray Data Analyzed to Identify Altered Metabolic Targets in HCC Patients

Accession number	Data compareda	Number of samples		Main etiology reported	Reference
		Control	HCC
GSE14520b	Paired NT vs HCC	220	225	HBV	[24]
GSE39791	Matched NT vs HCC	72	72	HBV	[25]
GSE57957	Adjacent NT vs HCC	39	39	HBV	[26]
GSE36376	AJCC Stage 3: Adjacent NT vs HCC	32	38	HBV	[27]
GSE60502	Adjacent NT vs HCC	18	18	NA	[28]
GSE14323c	Normal liver vs HCC	19	38	HCV	[29]
GSE6764	Normal liver vs very advanced HCC	10	10	HCV	[30]
GSE62232	Normal liver vs HCC	10	81	Mixed: alcohol, HBV, HCV, etc.d	[31]
Total arrays		420	521

HBV/HCV, hepatitis B/C virus; HCC, hepatocellular carcinoma; NA, detail could not be accessed; NT, nontumor.

^aDescription of the data compared as documented in the National Center for Biotechnology Information Gene Expression Omnibus. Differential expression was analyzed with GEO2R tool. The overall design for each dataset can be found at https://www.ncbi.nlm.nih.gov/geo/.

^bData platform analyzed was GPL3921.

^cData platform analyzed was GPL571.

^dIncludes unknown etiology, hemochromatosis, metabolic syndrome and combinations of alcohol with the other etiologic factors.