Table 2.
Selection of Metabolic Targets From the List of Deregulated Gene Probes in Each HCC Dataset Used in This Study
| HCC microarrays | logFC generated via NCBI GEO2R (P < .05) |
Number of metabolic genes selected |
|||
|---|---|---|---|---|---|
| Mean | SD | T used for selecting metabolic genes | Up-regulated (≥ +T) | Down-regulated (≤ -T) | |
| GSE14520 | 0.0295 | 0.598 | 0.2 | 542 | 654 |
| GSE39791 | 0.0102 | 0.3772 | 0.15 | 551 | 653 |
| GSE57957 | 0.0225 | 0.415 | 0.15 | 623 | 650 |
| GSE36376 | 0.275 | 0.484 | 0.1 | 934 | 404 |
| GSE60502 | 0.000321 | 0.976 | 0.4 | 340 | 597 |
| GSE14323 | –0.015 | 0.563 | 0.15 | 473 | 683 |
| GSE6764 | 0.0196 | 1.00129 | 0.45 | 437 | 628 |
| GSE62232 | 0.0104 | 0.6383 | 0.25 | 552 | 814 |
Mean and SD were calculated from all probe sets with logFC values at P < .05 (including metabolic and other genes). Metabolic genes with +logFC at and above threshold (T) were selected as up-regulated targets; those with –logFC at or below T selected as down-regulated targets.
HCC, hepatocellular carcinoma; logFC, log of fold change; NCBI, National Center for Biotechnology Information.