. 2017 May 31;4(2):303–323.e1. doi: 10.1016/j.jcmgh.2017.05.004

Table 3.

Family of Metabolic Targets Consistently Expressed in the Opposite Direction in HCC

Metabolic processes	Up-regulated	Down-regulated
ABC transporters	ABCC4, ABCC5, ABCC10	ABCC6, ABCC9
Cholesterol trafficking	NPC1, NPC2	NPC1L1
Fatty acid biosynthesis	ACACA^a	ACACB^a
√	ACSL3^a, ACSL4^a	ACSL1^a, ACSL5^a
√	ELOVL5	ELOVL6
Fatty acid/phospholipids	PLA2G4C, PLA2G7	PLA2G16
Folate metabolism	MTHFR	MTHFD1^a, MTHFS^a
Glutaminolysis	GLS	GLS2^a
Glutathione metabolism	GSTA4	GSTA1, GSTA3, GSTZ1
Glycerophospholipid biosynthesis	ABHD4	ABHD2, ABHD6, ABHD10
Glycogenesis	G6PC3	G6PC
√	GYG1^a	GYG2
Glycolysis	ALDOA^a	ALDOB^a
√	ENO1^a	ENO3^a
√	PFKP	PFKFB1
Glycolysis-TCA cycle junction	MPC2	MPC1
Glycoprotein/glycolipids Metabolism	B4GALT3, B4GALT7	B4GALT1
Glycosaminoglycan metabolism	B3GAT3	B3GAT1
√	NDST1	NDST3
√	PAPSS1	PAPSS2^a
Lysophosphatidic acid synthesis	ENPP2, ENPP4	ENPP1
Oxidative stress	PON2	PON1^a, PON3^a
Phospholipid	AGPAT1	AGPAT2
Purine biosynthesis	NUDT1, NUDT2	NUDT7
S-adenosylmethionine	MAT1A^a	MAT2A
Sphingolipid metabolism	PPAP2A	PPAP2B
Steroid biosynthesis	ACBD3^a	ACBD4
Second messenger molecule synthesis	PDE6D	PDE2A, PDE7B
√	PLCG1	PLCG2
Xenobiotics	NAT9, NAT10	NAT2
√	SULT1C2	SULT1A1^a, SULT1A2, SULT2A1^a
Transporters	SLC16A3	SLC16A2, SLC16A10, SLC16A4
√	SLC22A5	SLC22A1
√	SLC25A6^a, SLC25A3^a	SLC25A15, SLC25A16 SLC25A20^a, SLC25A37
Glucose transporters	SLC2A5, SLC2A6	SLC2A2
Transporters	SLC38A1, SLC38A6	SLC38A2, SLC38A4
√	SLC39A1, SLC39A6	SLC39A14, SLC39A8
√	SLC4A2, SLC4A7	SLC4A4
√	SLC6A8	SLC6A12, SLC6A13, SLC6A16
√	SLC7A1, SLC7A6, SLC7A11	SLC7A2, SLC7A8
Organic anion transport	SLCO2A1	SLCO2B1
Lipid binding/unclear	STARD7	STARD5

ABC, adenosine triphosphate–binding cassette; HCC, hepatocellular carcinoma; TCA, tricarboxylic acid.

Also detected to be significantly deregulated at protein level in our analysis.