Table 5.
Genes in Mainly Up-Regulated Pathways That Correlated With the Expression of Progression Markers and Predicted Survival Outcome in HCC Patients
| Metabolic process | Gene symbol | # of datasets | Expression | Correlationa |
Predicts overall survivalb | |
|---|---|---|---|---|---|---|
| CDH1 | VIM | |||||
| Glycolysis | ▪PFKFB1 | 6 | Down | c | .0202 | |
| ALDOB | 8 | Down | c | c | .0022d | |
| ALDOA | 8 | Up | c | .0001d | ||
| HK2 | 6 | Up | c | .0001d | ||
| PKM | 8 | Up | c | .0003d | ||
| PDK4 | 7 | Down | .0177 | |||
| PPP | ▪DERA | 7 | Down | c | .0075 | |
| TKT | 7 | Up | c | .0132 | ||
| G6PD | 7 | Up | .0021d | |||
| TCA cycle | ▪ACO1 | 7 | Down | c | c | .0211 |
| ACLY | 7 | Up | .0054 | |||
| ME2 | 7 | Up | c | .0257 | ||
| OXPHOS | NDUFA4L2 | 7 | Up | .0003 | ||
| Nucleotide | ▪DPYS | 7 | Down | c | .0455 | |
| XDH | 7 | Down | c | c | .0047 | |
| UPB1 | 7 | Down | c | .0053 | ||
| ▪GMPS | 7 | Up | .0056 | |||
| ▪ADSL | 7 | Up | c | .0183 | ||
| ▪IMPDH2 | 8 | Up | c | .0085 | ||
| ▪NT5DC2 | 8 | Up | c | .0206 | ||
| RRM2 | 8 | Up | .0422 | |||
| UCK2 | 7 | Up | c | .0005 | ||
| ADA | 6 | Up | c | .0328 | ||
| Membrane lipid | ▪PLCB1 | 8 | Up | .0006 | ||
| ▪GPD1L | 8 | Up | c | .0029 | ||
| ▪LPIN2 | 7 | Down | c | .0154 | ||
| ▪PLCE1 | 8 | Up | c | .0459 | ||
| LPCAT1 | 7 | Up | c | .0001 | ||
| PTDSS2 | 6 | Up | .0005 | |||
| Glycan | ▪CTBS | 8 | Down | .0203 | ||
| ▪GAL3ST1 | 6 | Up | c | .0026 | ||
| ▪B3GALNT1 | 8 | Up | c | .013 | ||
| ▪NAGPA | 7 | Up | c | .0325 | ||
| ▪DDOST | 7 | Up | .0401 | |||
| SULF1 | 7 | Up | c | .0291 | ||
| Cholesterol | ▪HMGCS2 | 7 | Down | c | .0002 | |
| LCAT | 8 | Down | .0165 | |||
| ▪LBR | 7 | Up | .0269 | |||
Kaplan-Meier overall survival was calculated for each gene and statistical significance analyzed by log-rank (Mantel-Cox) test. Square (▪) indicates novel targets in liver cancer as determined by PubMed search.
#, number of datasets in which each gene is expressed at P < .05.
All listed metabolic genes correlated with ECM2 and MMP9.
Denotes P value.
Indicates those that also correlated with CDH1 and or VIM (Pearson correlation was considered significant at P < .05).
Previously identified as a survival predictor in hepatocellular carcinoma (HCC) (see the referenced study and other similarly described targets in Supplementary Table 1).