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. 2017 Aug 16;8:405. doi: 10.3389/fneur.2017.00405

Figure 2.

Figure 2

Immunofluorescent labeling for nodal and axon initial segment (AIS) marker ankyrin-G (Ank-G, red) and paranodal marker contactin-associated protein (caspr, green) in controls (A,B) and cases (C,D). Labeling of AIS and nodal and paranodal axonal microdomains in cortical tissue from control cases reveals a regular pattern multiple intact node/paranode complexes (A) and multiple AISs (B). In cortical tissue adjacent to a microinfarct from two different cases (C,D), the frequency of intact AIS is dramatically reduced. Similarly, intact node/paranode complexes are rarely identified and when present often show paranodal elongation [inset (C)]. Inset: magnification ×60, scale bar = 5 µm.