Figure 3.

Additional examples of axonal microdomain disruption are apparent immediately adjacent to microinfarcts. Elongated and irregular contactin-associated protein (caspr)-positive paranodes (green) are frequently seen (A). In tissue adjacent to, but some distance from the infarct core (300–350 µm away from infarct core), axonal microdomains remain disrupted with irregular morphology of paranodal regions [inset (B)]. In some instances, Ankyrin-G (Ank-G)-positive axon initial segments can be identified [arrowheads, insets (C,D)]. Inset: magnification ×60, scale bar = 5 µm.