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. 2017 Aug 16;8:389. doi: 10.3389/fneur.2017.00389

Figure 2.

Figure 2

Diagnostic process and PCA classification. Key diagnostic questions at each level are shown in boxes. Syndrome-level descriptions (classification levels 1 and 2) are lightly shaded and disease-level descriptions (classification level 3) are darkly shaded. Among the disease-level classifications, PCA-AD and PCA-prion (solid ovals) are distinguished from PCA-LBD and PCA-CBD (dashed ovals) owing to the current availability of in vivo pathophysiological biomarkers. Other disease-level classifications may be appropriate (e.g., a patient with PCA plus visual hallucinations may have LBD-variant of AD) or anticipated (e.g., PCA attributable to GRN mutations). The thickness of lines connecting classification levels 2 and 3 is intended to reflect the status of AD as the most common cause of PCA. Abbreviations: AD, Alzheimer’s disease; CBD, corticobasal degeneration; LBD, Lewy body disease; PCA, posterior cortical atrophy; tbc, to be confirmed. Reproduced from Crutch et al. (52), available under the terms of Creative Commons Attribution License (CC BY 4.0).