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Tocilizumab did not inhibit IL-6 secretion of lipopolysaccharide (LPS)-activated dendritic cells (DCs). iDC were pretreated with the whole tocilizumab (toci) or rituximab (ritux) antibodies (A) or F(ab′)2 (B) of tocilizumab (TFab) or rituximab (RFab) (50 µg/ml) for 30 min prior to maturation with 50 ng/ml LPS during 48 h. ELISA assessed IL-6 secretion in supernatants. Results are expressed as mean ± SD (n = 8). “***” indicates statistical difference with p < 0.001.
