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. 2017 Aug 17;7:8535. doi: 10.1038/s41598-017-08906-x

Table 3.

Mean survival and time to median mortality of mosquitoes feeding on blood samples with matching concentrations (+/−1 ng/ml) of ivermectin with (K) or without ketoconazole at CYP inhibition concentrations.

Pair Drug concentrations Mean survival (days) Time to median mortality (days)
1 IVM 9.98 6.73 (6.29–7.17) 7
KET 8.96 5.39 (4.90–5.89) 5
2 IVM 16.5 5.11 (4.63–5.86) 5
KET 17.23 3.79 (3.49–4.09) 4
3 IVM 20.46 7.43 (7.11–7.75) 7
KET 20.39 5.10 (4.51–5.69) 4
4 IVM 27.58 5.28 (4.54–6.02) 5
KET 27.68 4.23 (3.80–4.65) 4

Footnote: IVM: ivermectin alone group, KET: ketoconazole + ivermectin group.