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. 2017 Aug 17;7:8687. doi: 10.1038/s41598-017-08726-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Kidney functional and structural parameters and markers of apoptosis and cell proliferation in renal parenchyma after ischemia/reperfusion according to the timing administration of MSC. (a–d) Lewis rats underwent i.v. injection of MSC 7 days before (MSCD − 7, n = 11) or 1 day after (MSCD + 1, n = 9) renal I/R. Control group received equal volume of saline at the same time-points (SD − 7, n = 6; SD + 1, n = 6) (a,b) Serum creatinine (SCr) and blood urea nitrogen (BUN) levels were measured at 48 h post renal I/R. (c) Histologic damage was graded on PAS-stained kidney sections following Jablonski score⁶³. Results are shown as medians and interquartile range. (d,e) Real-time qPCR quantification of mRNA expression levels of Bax, Bcl-2, Caspase-3 (Casp3), Heat-Shock Protein 70 (Hsp70), Kidney Injury Molecule 1 (Kim-1), Intercellular Adhesion Molecule 1 (Icam-1), Tumor Necrosis Factor alpha (Tnfα), Interleukine 6 (IL-6), Monocyte Chemotactic Protein 1 (Mcp-1), inducible NO synthase (iNOS) and arginase (Arg) in the kidney after 45 minutes of ischemia followed by 48 hours of reperfusion in SD − 7 versus MSCD − 7 groups (d) and in SD + 1 versus MSCD + 1 groups (e). The mRNA expression levels were standardized using Gapdh as housekeeping gene. Significant differences are indicated, *p ≤ 0.05, **p ≤ 0.01 and ***p ≤ 0.001.