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. 2017 Aug 17;7:8687. doi: 10.1038/s41598-017-08726-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Impact of MSC on lipid metabolism. (a) Significantly differentially expressed genes involved in fatty acid biosynthesis and nuclear receptor in lipid metabolism pathways in non-ischemic kidneys exposed to MSC (MSCD − 7, n = 6) versus saline (SD − 7, n = 6) 7 days before renal I/R, on the basis of the high-throughput RNA-sequencing. Data are shown in Fragments Per KiloBase per Million of mapped reads value. (b) RT-qPCR analysis of the genes corresponding to panel (a). The mRNA expression levels were standardized using GAPDH as housekeeping gene. (c,d) Quantification of PPARα, phospho-PPARα and CD36 expression in non-ischemic (panel c) and ischemic (panel d) kidneys. (e) Immunohistochemistry for FAT/CD36 in non-ischemic kidneys. (f–h) Representative immunochemistry of malondialdehyde (MDA) in renal parenchyma and quantitative immunoblotting of 4-hydroxy-2-nonenal (4-HNE) and MDA modified proteins (arrowheads) in ischemic kidneys of SD − 7 and MSCD − 7 groups (Ig, Immunoglobulins). Data are presented as mean ± standard deviation. Significant differences are indicated, *p ≤ 0.05, **p ≤ 0.01 and ***p ≤ 0.001 versus appropriate control group.