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. 2017 Aug 17;7:8603. doi: 10.1038/s41598-017-09152-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cardiac Architecture and Function Following Doxorubicin Treatment and Inhibition of the Notch Pathway with DAPT. (A) Evolution of cardiac architecture following doxorubicin treatment. Following inhibition of the Notch pathway with DAPT, the heart failed to regenerate by day 60. (B, C) Evolution of cardiac function following doxorubicin treatment. Diastolic function (E/A ratios) (B) and combined systolic and diastolic function (MPI) (C) remained abnormal by day 60, indicating continued cardiac dysfunction in the presence of Notch pathway inhibition. *P < 0.05, **P < 0.01. DAPT: γ-secretase inhibitor. MPI: myocardial performance index.