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. 2017 Aug 17;7:8607. doi: 10.1038/s41598-017-08887-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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pFUS does not alter renal function, tissue architecture, or KIM1 expression at 1 or 30 days post-pFUS. (A) BUN and SCr values do not change between control mice (no pFUS) and mice at 1 or 30 days post-pFUS (p > 0.05; ANOVA). (B) H&E staining reveals consistent renal architecture between untreated controls and treated mice at 1 or 30 days. (C) Immunostaining for KIM1 demonstrates consistent expression between untreated controls and pFUS-treated kidneys at 1 or 30 days. For AKI positive control, kidneys were harvested 4 days after i.p. injection with cisplatin (15 mg/kg). The AKI kidney did not receive pFUS. (D) The appearance of TUNEL-positive cells in pFUS treated kidneys at 30 min, 8 hr, or 30 days post-pFUS was similar to unsonicated kidneys. Scale bars = 50 μm.