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. 2017 Aug 17;7:8675. doi: 10.1038/s41598-017-09077-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Differences between the classes of antidepressant medication in the whole-brain resting-state functional connectivity maps with seed region in the dorsal raphe nucleus (DRN). Depressed patients with an SSRI demonstrated stronger FC from DRN to the posterior brain regions in contrast to patients taking an SNRI/NaSSA (blue color). In the opposite contrast, patients with an SNRI/NaSSA showed stronger FC to the right DLPF and VLPFC (yellow color). Abbr.: SSRI, selective serotonin re-uptake inhibitor; SNRI, serotonin and noradrenalin reuptake inhibitor; NaSSA, noradrenergic and specific serotonergic antidepressant; DLPFC, dorsolateral prefrontal cortex; VLPFC, ventrolateral prefrontal cortex; OCx, occipital cortex; Cereb., cerebellum.