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. 2017 Aug 17;7:8675. doi: 10.1038/s41598-017-09077-5

Figure 4.

Figure 4

Differences between the classes of antidepressant medication in the whole-brain resting-state functional connectivity maps with seed region in the locus coeruleus (LC). Depressed patients with an SNRI or NaSSA antidepressant demonstrated stronger FC from LC to the DLPFC, VMPFC and cerebellum in contrast to patients taking an SSRI. Abbr.: SSRI, selective serotonin re-uptake inhibitor; SNRI, serotonin and noradrenalin reuptake inhibitor; NaSSA, noradrenergic and specific serotonergic antidepressant; DLPFC, dorsolateral prefrontal cortex; VMPFC, ventromedial prefrontal cortex.