Table 2.
Hazard ratio for disease-free survival according to patient and tumor characteristics.
| Variable | Hazard ratio [95% CI] | p-value in univariate analysis |
|---|---|---|
| Age (years) >65 vs <65 | 1.52 [0.77–3.03] | 0.2238 |
| Gender Male/Female | 1.14 [0.55–2.36] | 0.7267 |
| Thrombosis Yes/No | 7.57 [0.58–99.38] | <0.0001 |
| Necrosis Yes/No | 4.02 [0.87–18.60] | 0.0008 |
| Sarcomatoid or rhabdoid Yes/No | 5.50 [1.49–20.40] | <0.0001 |
| Tumor grade 3–4/1–2 | 3.27 [1.55–6.93] | 0.0003 |
| T Stage 3–4/1–2 | 2.11 [0.72–6.19] | 0.0721 |
| Leibovich score ≥5/<5 | 4.11 [1.52–11.10] | <0.0001 |
| Leibovich score High vs. intermediate | 3.33 [1.11–9.99] | <0.0001 |
| Intermediate vs. low | 1.99 [0.80–4.93] | |
| High vs. low | 7.29 [1.63–32.58] | |
| MFI2-AS1 expression Yes/No | 3.50 [1.64–7.49] | 0.0001 |
| Hazard ratio [95% CI] | p-value in multivariate analysis | |
| Tumor grade *3–4/1–2 | 3.37 [1.68–6.76] | 0.0006 |
| MFI2-AS1 expression *Yes/No | 3.62 [1.80–7.27] | 0.0003 |
| Leibovich score ** ≥5/<5 | 5.18 [2.49–10.81] | <0.0001 |
| MFI2-AS1 expression **Yes/No | 4.24 [2.07–8.70] | 0.0001 |
*Multivariate analysis according to MFI2-AS1 expression, T stage and grade. **Multivariate analysis according to MFI2-AS1 expression and Leibovich score.