Table 2. Association results of rs13382811 and rs6469937 in the Guangzhou cohort.
|
SNPs |
rs13382811 (ZFHX1B) |
rs6469937 (SNTB1) |
||||
|---|---|---|---|---|---|---|
| Phenotype | myopia (n=300) | controls (n=308) | myopia (n=299) | controls (n=308) | ||
| Allelic Analysis |
|
|
|
|
|
|
| Alleles (%) |
C |
437 (72.8%) |
504 (81.8%) |
A |
136 (22.7%) |
181 (29.4%) |
| |
T* |
163 (27.2%) |
112 (18.2%) |
G* |
462 (77.3%) |
435 (70.6%) |
| HWE P |
|
0.05 |
0.05 |
|
0.42 |
0.35 |
| |
|
P# |
OR§ (95%CI) |
|
P# |
OR§ (95%CI) |
| Allelic P Values |
|
0.0001 |
1.68 (1.28–2.20) |
|
0.0085 |
0.71 (0.55–0.92) |
| Genotypic and Model Based Analysis |
|
|
|
|
||
| Genotypes (%) |
CC |
166 (55.3%) |
201 (65.3%) |
AA |
13 (4.3%) |
30 (9.7%) |
| |
CT |
105 (35.0%) |
102 (33.1%) |
AG |
110 (36.8%) |
121 (39.3%) |
| |
TT |
29 (9.7%) |
5 (1.6%) |
GG |
176 (58.9%) |
157 (51.0%) |
| |
|
P# |
OR§ (95%CI) |
|
P# |
OR§ (95%CI) |
| Genotypic test |
|
4.07×10−5 |
|
|
0.0166 |
|
| Additive (Trend) |
|
0.0002 |
|
|
0.0090 |
|
| Dominant |
|
0.0124 |
1.52 (1.09–2.10) |
|
0.0509 |
0.73 (0.53–1.00) |
| Recessive | 1.59×10−5 | 6.48 (2.48–16.99) | 0.0096 | 0.42 (0.22–0.82) | ||
*risk allele. # Chi-square p value. The correected significance level was 0.005 (α<0.05/10). §Odds ratios are calculated for the minor allele and genotypes.