Table 3. Association results of rs13382811 and rs6469937 in the Chaoshan cohort.
|
SNPs |
rs13382811 (ZFHX1B) |
rs6469937 (SNTB1) |
||||
|---|---|---|---|---|---|---|
| Phenotype | myopia (n=96) | controls (n=96) | myopia (n=95) | controls (n=95) | ||
| Allelic Analysis |
|
|
|
|
|
|
| Alleles (%) |
C* |
158 (82.3%) |
152 (79.2%) |
A |
41 (21.6%) |
56 (29.5%) |
| |
T |
34 (17.7%) |
40 (20.8%) |
G* |
149 (78.4%) |
134(70.5%) |
| HWE P |
|
0.16 |
0.26 |
|
0.80 |
0.11 |
| |
|
P# |
OR§ (95%CI) |
|
P# |
OR§ (95%CI) |
| Allelic P Values |
|
0.4376 |
0.82 (0.49–1.36) |
|
0.0780 |
0.66 (0.41–1.05) |
| Genotypic and Model Based Analysis |
|
|
|
|
||
| Genotypes (%) |
CC |
63 (65.6%) |
62 (64.6%) |
AA |
4 (4.2%) |
5 (5.3%) |
| |
CT |
32 (33.3%) |
28 (29.2%) |
AG |
33 (34.7%) |
46 (48.4%) |
| |
TT |
1 (1.0%) |
6 (6.3%) |
GG |
58 (61.1%) |
44 (46.3%) |
| |
|
P# |
OR§ (95%CI) |
|
P# |
OR§ (95%CI) |
| Genotypic test |
|
0.1462 |
|
|
0.1242 |
|
| Additive (Trend) |
|
0.4378 |
|
|
0.0645 |
|
| Dominant |
|
0.8797 |
0.96 (0.53–1.73) |
|
0.0417 |
0.55 (0.31–0.98) |
| Recessive | 0.0542 | 0.16 (0.02–1.34) | 0.7327 | 0.79 (0.21–3.04) | ||
*risk allele. # Chi-square p value. The correected significance level was 0.005 (α<0.05/10). §Odds ratios are calculated for the minor allele and genotypes.