Table 4. Association results of rs13382811 and rs6469937 in combined cohorts of Guangzhou and Chaoshan.
|
SNPs |
rs13382811 (ZFHX1B) |
rs6469937 (SNTB1) |
||||
|---|---|---|---|---|---|---|
| Phenotype | myopia (n=396) | controls (n=404) | myopia (n=394) | controls (n=403) | ||
| Allelic Analysis |
|
|
|
|
|
|
| Alleles (%) |
C |
595 (75.1%) |
656 (81.2%) |
A |
177 (22.5%) |
237 (29.4%) |
| |
T* |
197 (24.9%) |
152 (18.8%) |
G* |
611 (77.5%) |
569 (70.6%) |
| HWE P |
|
0.14 |
0.28 |
|
0.40 |
0.97 |
| |
|
P# |
OR§ (95%CI) |
|
P# |
OR§ (95%CI) |
| Allelic P Values |
|
0.0033 |
1.42 (1.13–1.81) |
|
0.0016 |
0.70 (0.55–0.87) |
| Genotypic and Model Based Analysis |
|
|
|
|
||
| Genotypes (%) |
CC |
229 (57.8%) |
263 (65.1%) |
AA |
17 (4.3%) |
35 (8.7%) |
| |
CT |
137 (34.6%) |
130 (32.2%) |
AG |
143 (36.3%) |
167 (41.4%) |
| |
TT |
30 (7.6%) |
11 (2.7%) |
GG |
234 (59.4%) |
201 (49.9%) |
| |
|
P# |
OR§ (95%CI) |
|
P# |
OR§ (95%CI) |
| Genotypic test |
|
0.0036 |
|
|
0.0053 |
|
| Additive (Trend) |
|
0.0037 |
|
|
0.0015 |
|
| Dominant |
|
0.0346 |
1.36 (1.02–1.81) |
|
0.0070 |
0.68 (0.51–0.90) |
| Recessive | 0.0019 | 2.93 (1.45–5.93) | 0.0125 | 0.47 (0.26–0.86) | ||
*risk allele. # Chi-square p value. The correected significance level was 0.005 (α<0.05/10). §Odds ratios are calculated for the minor allele and genotypes.