Table 5. Association results of rs13382811 and rs6469937 in the KORA cohort.
|
SNPs |
rs13382811 (ZFHX1B) |
rs6469937 (SNTB1) |
||||
|---|---|---|---|---|---|---|
| Phenotype | myopia (n=526) | controls (n=413) | myopia (n=526) | controls (n=413) | ||
| Allelic Analysis |
|
|
|
|
|
|
| Alleles (%) |
C* |
928 (88.2%) |
718 (86.9%) |
A* |
670 (63.7%) |
510 (61.7%) |
| |
T |
124 (11.8%) |
108 (13.1%) |
G |
382 (36.3%) |
316 (38.3%) |
| HWE P |
|
0.77 |
0.68 |
|
0.21 |
0.91 |
| |
|
P# |
OR§ (95%CI) |
|
P# |
OR§ (95%CI) |
| Allelic P Values |
|
0.3998 |
0.89 (0.67–1.17) |
|
0.3867 |
0.92 (0.76–1.11) |
| Genotypic and Model Based Analysis |
|
|
|
|
||
| Genotypes (%) |
CC |
410 (78.0%) |
313 (75.8%) |
AA |
220 (41.8%) |
158 (38.3%) |
| |
CT |
108 (20.5%) |
92 (22.3%) |
AG |
230 (43.7%) |
194 (47.0%) |
| |
TT |
8 (1.5%) |
8 (1.9%) |
GG |
76 (14.4%) |
61 (14.8%) |
| |
|
P# |
OR§ (95%CI) |
|
P# |
OR§ (95%CI) |
| Genotypic test |
|
0.7027 |
|
|
0.5251 |
|
| Additive (Trend) |
|
0.4039 |
|
|
0.3947 |
|
| Dominant |
|
0.4350 |
0.89 (0.65–1.20) |
|
0.2684 |
0.86 (0.66–1.12) |
| Recessive | 0.6248 | 0.78 (0.30–2.10) | 0.8900 | 0.97(0.68–1.40) | ||
*risk allele. # Chi-square p value. The correected significance level was 0.005 (α<0.05/10). §Odds ratios are calculated for the minor allele and genotypes.