Table 6. Association results of rs13382811 and rs6469937 in the TwinsUK cohort.
|
SNPs |
rs13382811 (ZFHX1B) |
rs6469937 (SNTB1) |
||||
|---|---|---|---|---|---|---|
| Phenotype | myopia (n=562) | controls (n=922) | myopia (n=562) | controls (n=922) | ||
| Allelic Analysis |
|
|
|
|
|
|
| Alleles (%) |
C* |
963 (85.68%) |
1531 (83.03%) |
A |
720 (64.06%) |
1239 (67.19%) |
| |
T |
161 (14.32%) |
313 (16.97%) |
G* |
404 (35.94%) |
605 (32.81%) |
| HWE P |
|
0.06 |
0.42 |
|
0.24 |
0.68 |
| |
|
P# |
OR§ (95%CI) |
|
P# |
OR§ (95%CI) |
| Allelic P Values |
|
0.0559 |
0.82 (0.66–1.00) |
|
0.0804 |
1.15 (0.98–1.34) |
| Genotypic and Model Based Analysis |
|
|
|
|
||
| Genotypes (%) |
CC |
418 (74.38%) |
639 (69.31%) |
AA |
237 (42.10%) |
419 (45.44%) |
| |
CT |
127 (22.56%) |
253 (27.44%) |
AG |
246 (43.77%) |
401 (43.49%) |
| |
TT |
17 (3.02%) |
30 (3.25%) |
GG |
79 (14.03%) |
102 (11.06%) |
| |
|
P# |
OR§ (95%CI) |
|
P# |
OR§ (95%CI) |
| Genotypic test |
|
0.1046 |
|
|
0.1809 |
|
| Additive (Trend) |
|
0.0617 |
|
|
0.0848 |
|
| Dominant |
|
0.0364 |
0.78 (0.61–0.98) |
|
0.218 |
1.14 (0.92–1.41) |
| Recessive | 0.807 | 0.93 (0.51–1.70) | 0.0873 | 1.31 (0.96–1.80) | ||
*risk allele. # Chi-square p value. The correected significance level was 0.005 (α<0.05/10). §Odds ratios are calculated for the minor allele and genotypes.