Table 7. Association results of rs13382811 and rs6469937 in combined KORA and TwinsUK cohorts.
|
SNPs |
rs13382811 (ZFHX1B) |
rs6469937 (SNTB1) |
||||
|---|---|---|---|---|---|---|
| Phenotype | myopia (n=1088) | controls (n=1335) | myopia (n=1088) | controls (n=1335) | ||
| Allelic Analysis |
|
|
|
|
|
|
| Alleles (%) |
C* |
1891 (86.90%) |
2249 (84.23%) |
A* |
1445 (66.41%) |
1694 (63.45%) |
| |
T |
285 (13.10%) |
421 (15.77%) |
G |
731 (33.59%) |
976 (36.55%) |
| HWE P |
|
0.09 |
0.32 |
|
0.76 |
0.08 |
| |
|
P# |
OR§ (95%CI) |
|
P# |
OR§ (95%CI) |
| Allelic P Values |
|
0.0088 |
0.80 (0.68–0.95) |
|
0.0319 |
0.88 (0.78–0.99) |
| Genotypic and Model Based Analysis |
|
|
|
|
||
| Genotypes (%) |
CC |
828 (76.10%) |
952 (71.31%) |
AA |
482 (44.30%) |
552 (41.35%) |
| |
CT |
235 (21.60%) |
345 (25.84%) |
AG |
481 (44.21%) |
590 (44.19%) |
| |
TT |
25 (2.30%) |
38 (2.85%) |
GG |
125 (11.49%) |
193 (14.46%) |
| |
|
P# |
OR§ (95%CI) |
|
P# |
OR§ (95%CI) |
| Genotypic test |
|
0.0290 |
|
|
0.0725 |
|
| Additive (Trend) |
|
0.0101 |
|
|
0.0346 |
|
| Dominant |
|
0.0076 |
0.78 (0.65–0.94) |
|
0.1438 |
0.89 (0.75–1.04) |
| Recessive | 0.3986 | 0.80 (0.48–1.34) | 0.0314 | 0.77 (0.60–0.98) | ||
*risk allele. # Chi-square p value. The correected significance level was 0.005 (α<0.05/10). §Odds ratios are calculated for the minor allele and genotypes.