Table 1.
Demographic characteristics, maltreatment history and OXTR genotypes for healthy controls and per diagnostic group
| Characteristic | Control (n = 387) | DEP- (n = 428) | ANX- (n = 243) | DEP + ANX (n = 1509) |
|---|---|---|---|---|
| % Female | 58.7 | 65.4 | 62.6 | 69.1 |
| Age in years (SD) | 43.0 (14.3) | 42.6 (12.9) | 41.9 (14.1) | 41.9 (12.5) |
| Education in years (SD) | 13.1 (3.3) | 12.5 (3.2) | 12.4 (3.2) | 11.8 (3.3) |
| % CM on interview | 17.6 | 38.7 | 34.3 | 57.6 |
| CTQ total score (SD) | 33.4 (9.7) | 39.4 (13.5) | 37.2 (11.9) | 43.9 (14.9) |
| LEIDS-R (SD) | 15.7 (12.3) | 30.1 (17.0) | 24.7 (15.2) | 42.4 (17.6) |
| ASI (SD) | 23.0 (5.2) | 25.5 (7.1) | 30.1 (9.5) | 32.6 (9.6) |
| OXTR SNP rs53576 | ||||
| % AA | 12.1 | 10.0 | 12.8 | 12.1 |
| % AG | 46.3 | 47.9 | 49.4 | 45.9 |
| % GG | 41.6 | 42.1 | 37.9 | 41.9 |
| OXTR SNP rs2254298 | ||||
| % AA | 1.0 | 0.5 | 0.4 | 0.4 |
| % AG | 8.0 | 16.1 | 9.1 | 11.1 |
| % GG | 91.0 | 83.4 | 90.5 | 88.5 |
| OXTR SNP rs2268498 | ||||
| % CC | 20.9 | 18.0 | 21.8 | 20.7 |
| % CT | 54.0 | 53.5 | 49.8 | 49.1 |
| % TT | 25.1 | 28.5 | 28.4 | 30.2 |
CM childhood maltreatment, CTQ Childhood Trauma Questionnaire, DEP depressive disorder, ANX anxiety disorder, - no comorbid depressive or anxiety disorder, OXTR oxytocin receptor, SNP single nucleotide polymorphism, LEIDS-R revised Leiden Index of Depression Sensitivity, ASI Anxiety Sensitivity Index