Table 3.
The effects of CM (interview and CTQ), the three OXTR SNPs, and their interactions on depression sensitivity (LEIDS-R) and anxiety sensitivity (ASI)
| Outcome | Direct effect | SNP × CM-interview | SNP × CM-CTQ | |||
|---|---|---|---|---|---|---|
| Beta | p value | Beta | p value | Beta | p value | |
| LEIDS-R | ||||||
| CM interview | 0.32 | <0.001 | ||||
| CM-CTQ | 0.36 | <0.001 | ||||
| rs53576_A | 0.39 | 0.64 | 0.01 | 0.71 | −0.004 | 0.91 |
| rs2254298_A | 0.02 | 0.41 | 0.02 | 0.54 | 0.02 | 0.30 |
| rs2268498_C | −0.01 | 0.50 | −0.004 | 0.92 | 0.05 | 0.26 |
| ASI | ||||||
| CM interview | 0.13 | <0.001 | ||||
| CM-CTQ | 0.16 | <0.001 | ||||
| rs53576_A | 0.03 | 0.11 | 0.01 | 0.72 | −0.02 | 0.56 |
| rs2254298_A | 0.01 | 0.54 | 0.05 | 0.12 | 0.009 | 0.71 |
| rs2268498_C | −0.009 | 0.68 | 0.01 | 0.77 | 0.009 | 0.83 |
The direct effects of the SNPs, CM and their interaction effects (SNP*CM) on the two outcomes were estimated in separate multiple regression models including age, gender, and education as covariates. The models estimating SNP*CM also included the main effects of the concerning SNP and CM
CM Childhood Maltreatment, CTQ Childhood Trauma Questionnaire, SNP single nucleotide polymorphism