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. 2017 Aug 17;7:8608. doi: 10.1038/s41598-017-09111-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Sequence similarity clustering of all MCE proteins. A representative subset of MCE proteins (including those found in eukaryotes) were clustered based on similarity, as determined by BlastP. A node represents a protein and an edge (line) indicates an interaction between two proteins. The cluster diagram is coloured by (A) protein architecture and (B) phylum.