Table 3.
Hair cortisol regressed on individual pigmentation SNPs in multi-ancestry sample (n = 1674).
Predictor | Seperate models (no ancestry correction) | Mutually Adjusted (no ancestry correction) | Seperate models (ancestry correction) | Mutually Adjusted (ancestry correction) | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
β | SE | p | β | SE | p | β | SE | p | β | SE | p | |
rs885479 | −0.04 | 0.07 | 6E-01 | 0.04 | 0.07 | 6E-01 | −0.01 | 0.07 | 9E-01 | −0.02 | 0.08 | 8E-01 |
rs1805008 | 0.23 | 0.07 | 1E-03 | 0.19 | 0.07 | 1E-02 | 0.14 | 0.07 | 5E-02 | 0.13 | 0.07 | 7E-02 |
rs1805005 | 0.02 | 0.08 | 8E-01 | 0.01 | 0.08 | 9E-01 | −0.10 | 0.08 | 2E-01 | −0.06 | 0.08 | 4E-01 |
rs1805007 | 0.19 | 0.09 | 3E-02 | 0.11 | 0.09 | 2E-01 | 0.04 | 0.08 | 6E-01 | 0.05 | 0.09 | 6E-01 |
rs2228479 | 0.03 | 0.07 | 6E-01 | 0.05 | 0.07 | 5E-01 | 0.00 | 0.07 | 1E + 00 | 0.00 | 0.07 | 1E+00 |
rs28777 | −0.40 | 0.05 | 8E-18 | 0.02 | 0.15 | 9E-01 | −0.10 | 0.06 | 9E-02 | −0.01 | 0.15 | 1E+00 |
rs16891982 | 0.39 | 0.04 | 7E-20 | 0.31 | 0.14 | 3E-02 | 0.11 | 0.06 | 8E-02 | 0.10 | 0.15 | 5E-01 |
rs2402130 | −0.11 | 0.04 | 7E-03 | −0.02 | 0.04 | 7E-01 | −0.01 | 0.04 | 7E-01 | −0.02 | 0.05 | 7E-01 |
rs12896399 | 0.13 | 0.03 | 2E-04 | 0.03 | 0.04 | 4E-01 | −0.01 | 0.04 | 8E-01 | −0.02 | 0.04 | 7E-01 |
rs1042602 | 0.03 | 0.04 | 4E-01 | 0.01 | 0.04 | 7E-01 | −0.04 | 0.04 | 3E-01 | −0.02 | 0.04 | 6E-01 |
rs1393350 | 0.18 | 0.04 | 3E-05 | 0.11 | 0.05 | 2E-02 | 0.08 | 0.04 | 6E-02 | 0.07 | 0.05 | 1E-01 |
rs12821256 | 0.19 | 0.06 | 2E-03 | 0.07 | 0.06 | 2E-01 | 0.02 | 0.06 | 7E-01 | 0.02 | 0.06 | 7E-01 |
rs4959270 | 0.05 | 0.04 | 1E-01 | 0.04 | 0.03 | 3E-01 | 0.01 | 0.03 | 8E-01 | 0.02 | 0.03 | 5E-01 |
rs12203592 | −0.07 | 0.07 | 3E-01 | −0.15 | 0.07 | 3E-02 | −0.16 | 0.06 | 2E-02 | −0.17 | 0.07 | 1E-02 |
rs1800407 | 0.01 | 0.12 | 9E-01 | 0.07 | 0.11 | 6E-01 | 0.04 | 0.12 | 7E-01 | 0.05 | 0.12 | 6E-01 |
rs2378249 | 0.11 | 0.05 | 2E-02 | 0.13 | 0.04 | 5E-03 | 0.10 | 0.05 | 3E-02 | 0.11 | 0.05 | 2E-02 |
rs683 | 0.20 | 0.03 | 7E-10 | 0.12 | 0.03 | 3E-04 | 0.05 | 0.04 | 1E-01 | 0.06 | 0.04 | 8E-02 |
SNPs were either included in separate models or mutually adjusted in a single model. Positive coefficients indicate increases in hormone concentrations per effect allele (see Table S1, available).