Table 1.

The specific parameters in binding and uptake assays.

	Binding Ki (nM)		[3H]5-HT uptake IC50 (nM)
	C57BL6	DBA/2J	C57BL6	DBA/2J
Fluoxetine	1.47 ± 0.25	132 ± 0.35***	2.74 ± 0.85	860 ± 24.45***
Citalopram	734 ± 28.7	1.28 ± 0.58***	214 ± 27.75	1.34 ± 0.35***
Paroxetine	0.45 ± 0.21	0.14 ± 0.05	0.85 ± 0.15	0.57 ± 0.27

Fluoxetine, citalopram and paroxetine compete for 5-HT transporter binding (specific [³H]paroxetine binding) and 10 nM [³H]5-HT reuptake into hippocampal synaptosomes in the two mouse strains. The IC₅₀ value was generated from each of these curves. Each data point depicted represents the mean ± S.E.M of 3–4 mice. ***p < 0.001, Student’s t-test.