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. 2017 Aug 17;7:8574. doi: 10.1038/s41598-017-08795-0

Figure 2.

Figure 2

Ethanol-induced conditioned place preference (CPP) in adolescent male Swiss mice, at test sessions 1, 2, 3 and 4. The line graphs depict time spent (in seconds or in percent preference, sections (A) and (C), respectively) in the chamber associated with ethanol’s effects (conditioned stimulus [CS+]), as a function of rearing condition (standard [control] conditions and environmental enrichment; SC and EE groups, respectively) and treatment during CPP training (vehicle or 2.0 g/kg ethanol). The small bar graphs (B and D) depict absolute (s) and percent time spent in the CS+ collapsed across test sessions. Animals that were given ethanol and were reared under EE conditions spent significantly more time in the chamber associated with ethanol than the rest of the animals that were treated with vehicle or ethanol, an effect that was statistically similar across test sessions. This significant effect is indicated by the asterisk sign. Values express mean ± SEM.