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. 2017 Aug 17;7:8574. doi: 10.1038/s41598-017-08795-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Ethanol-induced conditioned place preference (CPP) of adult male Swiss mice, at test sessions 1, 2, 3 and 4. The line graphs depict time spent (in seconds or in percent preference, sections (A) and (C), respectively) in the chamber associated with ethanol’s effects (conditioned stimulus [CS⁺]), as a function of rearing condition (standard [control] conditions and environmental enrichment; SC and EE groups, respectively) and treatment during CPP training (vehicle or 2.0 g/kg ethanol). The small bar graphs (B and D) depict absolute (s) and percent time spent in the CS⁺ collapsed across test sessions. Animals that were given ethanol spent significantly more time in the chamber associated with ethanol than animals that were treated with vehicle, an effect that was statistically similar across test sessions and in EE and SC subjects. This significant effect is indicated by the asterisk sign. Values express mean ± SEM.