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. 2017 Aug 17;7:8574. doi: 10.1038/s41598-017-08795-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Body weight (g, mean ± SEM) of male Swiss mice, prior to every administration of saline or ethanol (sessions 1 to 8) and prior to the habituation session, as a function of Age (adolescents or adults), Environmental condition (environmental enriched [EE] or standard housing conditions [SC]) and Treatment (4, every-other-day administrations of 0.0 [vehicle control] or 2.0 g/kg ethanol). The asterisk sign indicates that, throughout days, body weight was significantly lower in EE adolescent animals than in SC counterparts. The pound sign indicates a significant difference between EE adults given ethanol and vehicle, SC adults, during habituation and sessions 1 and 2.