FIG 2.

Biosynthetic gene clusters and LanA alignments of type 1 lanthipeptides identified in non-aureus staphylococci isolated from milk of Canadian dairy cows. (A) Biosynthetic gene clusters of type 1 lanthipeptides, with inhibiting non-aureus staphylococci isolates in boldface and identical precursors in different cluster organizations indicated by an asterisk. (B) Multiple-sequence alignments of LanA genes identified in type 1 lanthipeptide clusters and known bacteriocins nisin (accession number P13068), gallidermin (accession number P21838), epidermin (accession number P08136), epilancin K7 (accession number Q57312), pep5 (accession number P19578), and epicidin 280 (accession number O54220). +, the modal value of that column is shared by more than one residue.