FIG 6.
Inactivating mutation rates are unchanged in ADP1-ISx after deletion of error-prone polymerase DinP and DNA damage response regulator UmuDAb. The effects of deleting each gene on the rates of mutations inactivating the tdk counterselectable marker gene inserted into the genome at site 2 were measured for each strain. Mutation rates in ADP1-ISx and the umuDAb deletion strain were also determined in the presence of a subinhibitory concentration of nalidixic acid, which induces double-strand breaks in DNA. The error bars are 95% confidence intervals.