Table 3.
The top 10 enriched pathways by differentially expressed cytokines via different databases
| Category | Term | Count | p‐value |
|---|---|---|---|
| KEGG pathways | |||
| hsa04060 | Cytokine–cytokine receptor interaction | 4 | .0100043 |
| hsa05144 | Malaria | 2 | .0110871 |
| hsa05214 | Glioma | 2 | .0186208 |
| hsa05212 | Pancreatic cancer | 2 | .0191468 |
| hsa05218 | Melanoma | 2 | .0218693 |
| hsa04540 | Gap junction | 2 | .0328786 |
| hsa05215 | Prostate cancer | 2 | .0328786 |
| hsa05323 | Rheumatoid arthritis | 2 | .0342118 |
| hsa05142 | Chagas disease (American trypanosomiasis) | 2 | .0433727 |
| hsa04010 | MAPK signaling pathway | 3 | .0477863 |
| Reactome | |||
| REACT_118779 | Extracellular matrix organization | 7 | 2.56E‐07 |
| REACT_163874 | Non‐integrin membrane‐ECM interactions | 7 | 3.77E‐07 |
| REACT_163906 | ECM proteoglycans | 9 | 1.77E‐05 |
| REACT_318 | Platelet degranulation | 6 | 4.38E‐04 |
| REACT_6323 | Host Interactions with Influenza Factors | 4 | 4.06E‐03 |
| REACT_1280 | Response to elevated platelet cytosolic Ca2+ | 11 | 2.37E‐06 |
| REACT_120996 | Hyaluronan uptake and degradation | 11 | 4.70E‐05 |
| REACT_120726 | TGF‐beta receptor signaling in EMT (epithelial to mesenchymal transition) | 6 | 7.15E‐04 |
| REACT_121083 | Hyaluronan metabolism | 4 | 3.05E‐03 |
| REACT_115852 | Signaling by constitutively active EGFR | 6 | 4.77E‐03 |
| PID | |||
| il27pathway | IL27‐mediated signaling events | 2 | .0051456 |
| ceramide_pathway | Ceramide signaling pathway | 2 | .0134937 |
| pdgf_pathway | PDGF receptor signaling network | 1 | .0267852 |
| telomerasepathway | Regulation of Telomerase | 2 | .0289511 |
| ap1_pathway | AP‐1 transcription factor network | 2 | .0313181 |
| et_egfrpathway | EGFR‐dependent Endothelin signaling events | 1 | .0380509 |
| erbb_network_pathway | ErbB receptor signaling network | 1 | .0602047 |
| syndecan_1_pathway | Syndecan‐1‐mediated signaling events | 1 | .0674790 |
| rxr_vdr_pathway | RXR and RAR heterodimerization with other nuclear receptor | 1 | .0995446 |
| alk1pathway | ALK1 signaling events | 1 | .0995446 |