Figure 2.

Knockdown of cacna1c in the PFC has an antidepressant-like effect in mice. (a) Experimental outline used. (b) Representative image of green fluorescent protein (GFP)-positive cells expressed by AAV-Cre stereotaxically injected into the PFC of cacna1c^fl/fl mice. (c) AAV-Cre and AAV-GFP mice travel similar distances in the basal locomotor activity test (AAV-GFP n=8, AAV-Cre n=8). (d) AAV-Cre mice show significantly higher sucrose consumption than control AAV-GFP mice in the sucrose preference test (AAV-GFP n=9, AAV-Cre n=8). (e) AAV-Cre mice spend significantly less time immobile in the forced swim test compared with control AAV-GFP mice (AAV-GFP n=6, AAV-Cre n=6). *p<0.05 vs AAV-GFP. Error bars are mean±SEM.