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. 2017 Feb 8;42(10):2011–2020. doi: 10.1038/npp.2017.1

Figure 1.

Figure 1

Conditioned aversive cue-induced phosphorylated MAP kinase (pERK) after conditioned sex aversion (CSA) (experiment 1). (a) Experimental design and timeline of experiment 1 showing 4 days of sex experience, followed 1 week later by 7 conditioning trials of CSA, and the final exposure to home cage or female for pERK analysis. (b–d) Numbers of pERK-immunoreactive neurons per mm2 (mean±SEM) in control males removed from home cage (control, white bars, n=5) or males exposed to the conditioned aversive cues, ie females (female, black bars, n=6). Cell counts are shown for (b) subregions of the medial prefrontal cortex (mPFC) and orbitofrontal cortex (OFC) (ACA, anterior cingulate area; PL, prelimbic cortex; IL, infralimbic cortex); (c) striatum and VTA (NAc, nucleus accumbens Core and Shell; CPU, caudate putamen; VTA, ventral tegmental area), and (d) amygdala (LA, lateral amygdala; BLA, basolateral amygdala; CeA, central amygdala). *Significant difference from home cage control group.