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Pharmacokinetics of tianeptine and the MC5 metabolite. (a) Chemical structures of tianeptine and its MC5 metabolite. (b) In vitro activities of tianeptine and MC5 in G protein BRET assays measuring activation of mouse and human MOR and DOR, data points represent mean EC50±SEM (μM); Plasma (c) and brain (d) concentrations±STD of tianeptine and MC5 in C57BL/6 mice following a single administration of tianeptine (30 mg/kg).
