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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Anesthesiology. 2017 Sep;127(3):502–514. doi: 10.1097/ALN.0000000000001719

Figure 2.

Figure 2

Bilateral DAMGO injection into the tPBN significantly reduced respiratory rate and drive in young and adult rabbits, which was reversible with local naloxone. A: PNG tracing during control and after drug injections in an individual adult rabbit. B: Summary data for changes in respiratory rate. C: Summary data for changes in other respiratory parameters. Grey bars: young (n=14). White bars: adult (n=11). Mean ± SD. * P<0.05, ** P<0.01 and *** P<0.001 indicate significant differences between drug application conditions (linear mixed model with factors: drug application and developmental age). There were no differences in drug effects between young and adult animals.