Table 1.

Pooled Data for Opioid-Sensitive Inputs to Inspiratory and Expiratory Phase Duration

Study	Input source	Input to TI	Input to TE
preBötC	FpreBötC	*−0.12 (−0.29 to 0.06)	0.15 (0.04 to 0.34)
	FNon-preBötC	0.57 (0.14 to 0.97)	#1.39 (0.73 to 2.27)
tPBN	FPBN	0.39 (0 to 0.63)	0.60 (0.33 to 0.72)
	FNon-PBN	0.22 (−0.03 to 0.47)	0.61 (0.26 to 1.01)

Inputs modulating phase duration (F) were computed separately for inspiratory (T_I) and expiratory (T_E) duration from our current study in the parabrachial nucleus (tPBN) and our previous study in the preBötzinger Complex (preBötC) ²³. There were no differences between young and adult animals (P=0.69 for T_I, P=0.385 for T_E). Values for both age groups were pooled in the table for readability. Negative inputs increases respiratory phase duration; positive inputs decrease respiratory phase duration.

^*: preBötC input to T_I (F_preBötC) was significantly different from pontine (P=0.024).

^#: F_Non-preBötC inputs to T_E were significantly larger than F_preBötC (P=0.0003). Differences in magnitude between F_Non-preBötC and F_PBN to T_I and T_E suggest additional opioid-sensitive inputs from other brainstem sites but this was not statistically significant. Median (25–75% range); mixed linear model with fixed effects age, study and input source.