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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Pain. 2017 Sep;158(9):1711–1722. doi: 10.1097/j.pain.0000000000000966

Figure 5.

Figure 5

URB597 increased mechanical response thresholds in C-fibers from HbSS-BERK sickle mice. Data show the mean (±SEM) log-transformed mechanical thresholds before and at 60, 90, and 120 min post-injection. Mechanical thresholds were elevated following URB597 and this was blocked by the CB1 receptor antagonist AM281. In contrast, the CB2 receptor antagonist AM630 failed to block the effect of URB597, and thresholds following AM630 + URB597 were decreased at 60, 90, and 120 min after injection. *p<.05, **p<.01, ***p≤.005 indicates a significant difference from the vehicle-treated group. ##p<.005, ###p≤.001 indicates significant differences from pre-injection.