Table 2.

Predictions on missense variants classified by Myriad Genetics

(i) BRCA1
Variant	True classification	MutPred score	MutPred2 score
p.Cys39Phe	deleterious	0.99	0.76
p.Tyr777Asp	benign	0.54	0.54
p.Ile1275Val	benign	0.20	0.02
p.Asp1546Glu	benign	0.11	0.03
(ii) BRCA2
Variant	True classification	MutPred score	MutPred2 score
p.Val211Leu	deleterious	0.24	0.29
p.Ile975Ser	deleterious	0.37	0.34
p.Arg2336Hisa	deleterious	0.69	0.15
p.Val3079Ile	deleterious	0.58	0.09
p.Leu2368Val	benign	0.19	0.09
p.Glu2956Ala	probably benign	0.23	0.18
p.Pro3243Leu	probably benign	0.35	0.21

^aPresent in both predictors’ training sets as a pathogenic variant