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. Author manuscript; available in PMC: 2018 Apr 1.
Published in final edited form as: J Neurosci Res. 2017 Feb 25;95(10):1906–1916. doi: 10.1002/jnr.24028

Fig. 7.

Fig. 7

Overview of potential molecular changes in synaptic and extrasynaptic GABA-A receptor subunit plasticity in the NSW model of perimenstrual catamenial epilepsy. A working model is devised to illustrate the alterations in pharmacology due to NSW-induced changes in extrasynaptic GABA-A receptor subunit composition within the hippocampus. NSW-induced upregulation of extrasynaptic δ-subunit-containing receptors may regulate tonic inhibition and neurosteroid sensitivity. Loss of such tonic inhibition in δKO mice leads to catamenial-like seizure exacerbation following NSW paradigm.